Fas ligand (FasL) Apoptosis

Characterization of resistance to a recombinant hexameric Fas–ligand (APO010) in human most cancers cell strains

A number of myeloma stays a hard-to-treat most cancers as all sufferers finally progress due to drug resistance. Thus, there’s a want for novel and non-cross-resistant therapy choices, and we aimed to deal with this problem by introducing a brand new immuno-oncology drug (APO010) in a number of myeloma therapy. APO010 is a hexameric Fas-ligand that mimics cytotoxic T-lymphocyte signaling via the Fas-receptor to induce apoptosis. APO010 is at the moment in scientific trials with a number of myeloma sufferers.

Thus, an understanding of the mechanisms contributing to resistance to APO010 shall be important for future scientific research with APO010, and it may be doable to develop methods to bypass this resistance. We developed APO010-resistant variants of human a number of myeloma cell strains (LP1, MOLP-8, and KMS-12-BM) and a human Burkitt’s lymphoma cell line (Raji) by exposing the cells to steadily rising concentrations of APO010 over a interval of 6-12 months.

The resistant cell strains have been characterised on the idea of immunocytochemistry, Fas-receptor protein expression, mRNA expression evaluation, and pathway evaluation. APO010-resistant cell strains exhibited a 4- to 520-fold enhance in resistance to APO010 and nonetheless remained delicate to different chemotherapeutics. Downregulation of the Fas-receptor protein expression was noticed in all resistant cell strains.

rHu CD40 Ligand
AK9162-0100	Akron Biotech	100µg	Ask for price

rHu CD40 Ligand
AK9162-1000	Akron Biotech	1mg	Ask for price

CD40 ligand protein
80R-4345	Fitzgerald	10 ug	EUR 327
Description: Purified Recombinant CD40 ligand protein (His tagged)

Human CD40 ligand (CD40LG)
1-CSB-RP060054h	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in E.coli

Human CD40 ligand (CD40LG)
1-CSB-YP004937HU1	Cusabio	EUR 430.00 EUR 234.00 EUR 1508.00 EUR 642.00 EUR 1009.00 EUR 291.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in Yeast

Rabbit CD40 ligand (CD40LG)
1-CSB-YP004937RB	Cusabio	EUR 679.00 EUR 335.00 EUR 2172.00 EUR 1051.00 EUR 1442.00 EUR 435.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in Yeast

Rabbit CD40 ligand (CD40LG)
1-CSB-EP004937RB	Cusabio	EUR 611.00 EUR 309.00 EUR 1827.00 EUR 939.00 EUR 1218.00 EUR 397.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in E.coli

CD40 Ligand/TRAP (Soluble)
PR27033	Neuromics	50 ug	EUR 507

CD40 Ligand (CD40LG) Antibody
20-abx306369	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

CD40 Ligand (CD40LG) Antibody
abx146725-100ug	Abbexa	100 ug	EUR 439

CD40 Ligand (CD40LG) Antibody
abx146726-100ug	Abbexa	100 ug	EUR 439

CD40 Ligand (CD40LG) Antibody
abx146208-100ug	Abbexa	100 ug	EUR 391

CD40 Ligand (CD40LG) Antibody
20-abx000686	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

CD40 Ligand (CD40LG) Antibody
20-abx211981	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

CD40 Ligand Recombinant Protein
96-984	ProSci	0.1 mg	EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand Recombinant Protein
96-985	ProSci	0.1 mg	EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand Recombinant Protein
91-009	ProSci	0.05 mg	EUR 364.25
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

CD40 Ligand Recombinant Protein
92-361	ProSci	0.05 mg	EUR 490.25
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

Mouse Cd40lg/ CD40 ligand ELISA Kit
E0252Mo	Sunlong	1 Kit	EUR 571

Recombinant Mouse soluble CD40 Ligand/TRAP
7-01474	CHI Scientific	5µg	Ask for price

Recombinant Mouse soluble CD40 Ligand/TRAP
7-01475	CHI Scientific	25µg	Ask for price

Recombinant Mouse soluble CD40 Ligand/TRAP
7-01476	CHI Scientific	1mg	Ask for price

Anti-CD40/Cd40 Antibody
A00068-1	BosterBio	100ug/vial	EUR 294

Macaca mulatta CD40 ligand (CD40LG)
1-CSB-EP004937MOW	Cusabio	EUR 611.00 EUR 309.00 EUR 1827.00 EUR 939.00 EUR 1218.00 EUR 397.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Macaca mulatta CD40 ligand(CD40LG),partial expressed in E.coli

CD40LG/TNFSF5 (Cd40 Ligand) Antibody
20-abx111483	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

CD40 Ligand (CD40LG) Antibody (HRP)
20-abx306370	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

CD40 Ligand (CD40LG) Antibody (FITC)
20-abx306371	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

CD40 Ligand (CD40LG) Antibody (Biotin)
20-abx306372	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

soluble CD40 Ligand / TRAP Protein
20-abx260376	Abbexa	EUR 230.00 EUR 1859.00 EUR 328.00	10 ug 1 mg 50 ug

soluble CD40 Ligand / TRAP Protein
20-abx260744	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Soluble CD40 Ligand / TRAP Protein
20-abx261655	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

Soluble CD40 Ligand Recombinant Protein
40-455-0005mg	ProSci	0.005 mg	EUR 259.25
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Soluble CD40 Ligand Recombinant Protein
40-455-0025mg	ProSci	0.025 mg	EUR 364.25
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)
CU78-10ug	Novoprotein	10ug	EUR 141
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)
CU78-1mg	Novoprotein	1mg	EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)
CU78-500ug	Novoprotein	500ug	EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)
CU78-50ug	Novoprotein	50ug	EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

anti-CD40
YF-PA10796	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to CD40

anti-CD40
YF-PA10797	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to CD40

anti-CD40
YF-PA23398	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to CD40

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Chicken CD40LG/ CD40 ligand ELISA Kit
E0014Ch	Sunlong	1 Kit	EUR 717

Pig CD40LG/ CD40 ligand ELISA Kit
E0034Pi	Sunlong	1 Kit	EUR 717

Bovine CD40LG/ CD40 ligand ELISA Kit
E0055Bo	Sunlong	1 Kit	EUR 717

Rat Cd40lg/ CD40 ligand ELISA Kit
E0179Ra	Sunlong	1 Kit	EUR 646

Human CD40 Ligand, CD40LG ELISA Kit
DEIA091	Creative Diagnostics	15 Plates	EUR 2408
Description: Human CD40 Ligand ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant CD40 Ligand in a sandwich ELISA format within the range of 50-3,000 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay CD40 Ligand in approximately 1,500 ELISA plate wells.

Human CD40LG/ CD40 ligand ELISA Kit
E0425Hu	Sunlong	1 Kit	EUR 537

Recombinant Human soluble CD40 Ligand/TRAP
7-01468	CHI Scientific	10µg	Ask for price

Recombinant Human soluble CD40 Ligand/TRAP
7-01469	CHI Scientific	50µg	Ask for price

Recombinant Human soluble CD40 Ligand/TRAP
7-01470	CHI Scientific	1mg	Ask for price

ELISA kit for Human CD40 ligand
EK1310	SAB	96 tests	EUR 452
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Bovine CD40 ligand
EK1311	SAB	96 tests	EUR 670
Description: Enzyme-linked immunosorbent assay kit for quantification of Bovine CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids.

Recombinant Human CD40 Ligand/CD40L/TNFSF5
CI56-10ug	Novoprotein	10ug	EUR 146
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5
CI56-1mg	Novoprotein	1mg	EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5
CI56-500ug	Novoprotein	500ug	EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5
CI56-50ug	Novoprotein	50ug	EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

QuickDetect? CD40 Ligand (Human) ELISA Kit
K4414-100	Biovision		EUR 588

CD40 Ligand Recombinant Protein (Animal Free)
40-759	ProSci	10 ug	EUR 269.75
Description: CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Mouse Anti-Human CD40 mAb
CM005-100ug	SAB	100ug	EUR 245

Mouse Anti-Human CD40 mAb
CM005-25ug	SAB	25ug	EUR 136

Anti-CD40 Antibody
PA1019	BosterBio	100ug/vial	EUR 294

Anti-CD40 Antibody
PA1019-1	BosterBio	100ug/vial	EUR 294

Anti-CD40 Antibody
PB10051	BosterBio	100ug/vial	EUR 294

Anti-CD40 Antibody
PB10052	BosterBio	100ug/vial	EUR 334

Anti-CD40 antibody
STJ118037	St John's Laboratory	100 µl	EUR 277
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Anti-CD40 antibody
STJ23000	St John's Laboratory	100 µl	EUR 277
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Anti-CD40 antibody
STJ16100844	St John's Laboratory	200 µg	EUR 814

Anti-CD40 antibody
STJ170001	St John's Laboratory	100 µg	EUR 341
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin

Anti-CD40 antibody
STJ97928	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to CD40.

Anti-CD40 antibody
STJ92128	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to CD40.

anti- CD40 antibody
FNab01477	FN Test	100µg	EUR 505.25
Description: Antibody raised against CD40

anti-CD40 (9G10)
LF-MA30304	Abfrontier	100 ul	EUR 486
Description: Mouse Monoclonal to CD40

Anti-CD40 antibody
PAab01477	Lifescience Market	100 ug	EUR 355

Anti-CD40 (1G1)
YF-MA12337	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to CD40

sCD40L Mouse, soluble CD40 Ligand/TRAPMouse Recombinant Protein, sf9
PROTP27548-1	BosterBio	Regular: 5ug	EUR 317
Description: sCD40 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 155 amino acids (112-260 a.a.) and having a molecular mass of 17.2kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).;sCD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant
P1174-10	Biovision		EUR 164

Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant
P1174-50	Biovision		EUR 555

Rhesus macaque CD40 Ligand / TNFSF5 Recombinant Protein
11-500	ProSci	0.1 mg	EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

Mouse Anti Human Cd40 Monoclonal Antibody
CABT-46037MH	Creative Diagnostics	0.1 mg	EUR 710

Rat Anti Mouse Cd40 Monoclonal Antibody
CABT-46051RM	Creative Diagnostics	0.1 mg	EUR 455

Mouse Anti-Human CD40 mAbConjugated Antibody
CCM005	SAB	100ul	EUR 397

Mouse Monoclonal Anti-Human CD40, Unlabeled
CD40UL-100	Alpha Diagnostics	100 ug	EUR 408

Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant
P1127-10	Biovision		EUR 142

Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant
P1127-50	Biovision		EUR 479

Anti-human CD40 antibody
STJ15100139	St John's Laboratory	250 µg	EUR 273
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation.

Anti-human CD40 antibody
STJ15100140	St John's Laboratory	250 µg	EUR 305
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections.

Anti-human CD40 antibody
STJ15100143	St John's Laboratory	250 µg	EUR 273
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation.

Anti-Hu CD40 FITC
1F-416-T025	ExBio	25 tests	EUR 122

Anti-Hu CD40 FITC
1F-416-T100	ExBio	100 tests	EUR 204

Anti-Hu CD40 PE
1P-416-T025	ExBio	25 tests	EUR 140

Anti-Hu CD40 PE
1P-416-T100	ExBio	100 tests	EUR 240

Recombinant Human soluble CD40 Ligand/TRAP His Tag
7-01471	CHI Scientific	5µg	Ask for price

Recombinant Human soluble CD40 Ligand/TRAP His Tag
7-01472	CHI Scientific	20µg	Ask for price

Recombinant Human soluble CD40 Ligand/TRAP His Tag
7-01473	CHI Scientific	1mg	Ask for price

Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli)
C011-10ug	Novoprotein	10ug	EUR 100
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli)
C011-1mg	Novoprotein	1mg	EUR 943
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

mRNA expression evaluation of the resistant versus parental cell strains confirmed a major alteration in FAS expression between delicate and resistant cell strains (p = 0.03), whereas pathway evaluation revealed alterations in mRNA signaling pathways of Fas. On the idea of the pre-clinical knowledge obtained, it may be concluded that downregulation of Fas-receptor can mediate resistance to APO010. Osteoclast exercise was assessed utilizing a pit formation assay. The mechanisms of inhibition have been studied by biochemical analyses, together with RT-PCR, immunofluorescent staining, circulation cytometry, an apoptosis assay, immunoblotting, and ELISA.