Association of Plasma Levels of FAS Ligand with Severity and Outcome of Sepsis

Association of Plasma Levels of FAS Ligand with Severity and Outcome of Sepsis

Association of Plasma Levels of FAS Ligand with Severity and Outcome of Sepsis

Ranges of the apoptosis regulator Fas ligand (FasL) are related to severity of sepsis, however its affiliation with the mortality of sepsis and necroptosis, a regulated cell loss of life mechanism, will not be but clear. We aimed to evaluate the affiliation of FasL stage with outcomes of sepsis and receptor interacting protein kinase-3 (RIPK3), an important necroptosis mediator, for figuring out the connection between FasL and necroptosis.
Plasma FasL and RIPK3 ranges have been measured by ELISA from prospectively enrolled critically-ill grownup sufferers. The most effective cut-off stage of FasL for 28-day mortality prediction was decided by Youden’s index. The affiliation between plasma ranges of FasL and RIPK3 was assessed by a linear regression methodology. B lymphocytes make a number of contributions to immune regulation together with manufacturing of antibodies with regulatory properties, launch of immune suppressive cytokines, and expression of death-inducing ligands.

Amongst 188 sufferers, 58 (30.9%) have been recognized with sepsis and 84 (44.7%) with septic shock, respectively. Plasma ranges of FasL elevated within the group order of management, sepsis, and septic shock teams (P for pattern < 0.001). For 142 sufferers with sepsis, organ dysfunction and septic shock have been extra prevalent within the group with plasma FasL ranges that have been increased than one of the best cut-off stage. A big distinction in mortality between excessive and low FasL sufferers was noticed as much as 90 days (Log-rank P = 0.013). FasL ranges didn’t considerably change over day Three and day 7. FasL ranges weren’t correlated with these of RIPK3.

Serum ranges of soluble Fas and Fas ligand in pregnant ladies who smoke

Cigarette smoking throughout being pregnant is related to lowered incidence of preeclampsia. Mechanisms of this affiliation are poorly understood. Cytokines, angiogenic and anti-angiogenic components are concerned within the pathogenesis of preeclampsia. Throughout regular being pregnant, Fas ligand (FasL) current on trophoblasts induces apoptosis of Fas bearing maternal immune cells. In preeclampsia, trophoblasts present elevated apoptosis with lowered expression of FasL. We decided serum ranges of cytokines, angiogenic (placental development issue), anti-angiogenic components (soluble endoglin, soluble fms-like tyrosine kinase-1), soluble Fas (sFas) and soluble FasL (sFasL) in smoking and non-smoking pregnant ladies.
Utilizing enzyme linked immunosorbent and multiplex assays, we prospectively analyzed serum ranges of angiogenic, anti-angiogenic components, cytokines, sFas and sFasL in normotensive smoking and non-smoking moms. Exclusion standards included maternal hypertension, autoimmune issues, rupture of membranes, proof of labor and drug use. We handled murine macrophages with DCR3 throughout receptor activator of nuclear issue kappa Β ligand- (RANKL-) plus IL-1α-induced osteoclastogenesis to observe osteoclast formation by tartrate-resistant acid phosphatase (TRAP) staining.
Of 100 ladies recruited to the examine, 51 have been within the non-smoking and 49 within the smoking group. Aside from decrease maternal age within the smoking group, there was no distinction in gestation, BMI, gravidity or ethnicity between the 2 teams. Ranges of angiogenic, anti-angiogenic components, cytokines and sFas have been related between the 2 teams however sFasL ranges have been considerably increased in smoking group (38 pg/ml vs. 16 pg/ml, p <0.001) and remained important after controlling for confounders.
Our examine demonstrates increased sFasL ranges in pregnant ladies who smoke. Greater sFasL could clarify the lowered incidence of preeclampsia in pregnant moms who smoke by inducing apoptosis of immune cells which can in any other case induce trophoblast apoptosis. MicroRNAs (miRNAs) are thought-about as essential modulators in myocardial ischemia and reperfusion (I/R) damage. The current examine aimed to analyze the expression and organic features of miR-214-5p through concentrating on Fas ligand (FASLG) in I/R damage.
Association of Plasma Levels of FAS Ligand with Severity and Outcome of Sepsis

Characterization of resistance to a recombinant hexameric Fasligand (APO010) in human most cancers cell strains

A number of myeloma stays a hard-to-treat most cancers as all sufferers finally progress due to drug resistance. Thus, there’s a want for novel and non-cross-resistant therapy choices, and we aimed to deal with this problem by introducing a brand new immuno-oncology drug (APO010) in a number of myeloma therapy. APO010 is a hexameric Fas-ligand that mimics cytotoxic T-lymphocyte signaling via the Fas-receptor to induce apoptosis. APO010 is at the moment in scientific trials with a number of myeloma sufferers.

Thus, an understanding of the mechanisms contributing to resistance to APO010 shall be important for future scientific research with APO010, and it may be doable to develop methods to bypass this resistance. We developed APO010-resistant variants of human a number of myeloma cell strains (LP1, MOLP-8, and KMS-12-BM) and a human Burkitt’s lymphoma cell line (Raji) by exposing the cells to steadily rising concentrations of APO010 over a interval of 6-12 months.

The resistant cell strains have been characterised on the idea of immunocytochemistry, Fas-receptor protein expression, mRNA expression evaluation, and pathway evaluation. APO010-resistant cell strains exhibited a 4- to 520-fold enhance in resistance to APO010 and nonetheless remained delicate to different chemotherapeutics. Downregulation of the Fas-receptor protein expression was noticed in all resistant cell strains.

rHu CD40 Ligand

AK9162-0100 100µg Ask for price

rHu CD40 Ligand

AK9162-1000 1mg Ask for price

CD40 ligand protein

80R-4345 10 ug
EUR 327
Description: Purified Recombinant CD40 ligand protein (His tagged)

Human CD40 ligand (CD40LG)

1-CSB-RP060054h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in E.coli

Human CD40 ligand (CD40LG)

1-CSB-YP004937HU1
  • EUR 430.00
  • EUR 234.00
  • EUR 1508.00
  • EUR 642.00
  • EUR 1009.00
  • EUR 291.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in Yeast

Rabbit CD40 ligand (CD40LG)

1-CSB-YP004937RB
  • EUR 679.00
  • EUR 335.00
  • EUR 2172.00
  • EUR 1051.00
  • EUR 1442.00
  • EUR 435.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in Yeast

Rabbit CD40 ligand (CD40LG)

1-CSB-EP004937RB
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in E.coli

CD40 Ligand/TRAP (Soluble)

PR27033 50 ug
EUR 507

CD40 Ligand (CD40LG) Antibody

20-abx306369
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

CD40 Ligand (CD40LG) Antibody

abx146725-100ug 100 ug
EUR 439

CD40 Ligand (CD40LG) Antibody

abx146726-100ug 100 ug
EUR 439

CD40 Ligand (CD40LG) Antibody

abx146208-100ug 100 ug
EUR 391

CD40 Ligand (CD40LG) Antibody

20-abx000686
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

CD40 Ligand (CD40LG) Antibody

20-abx211981
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

CD40 Ligand Recombinant Protein

96-984 0.1 mg
EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand Recombinant Protein

96-985 0.1 mg
EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

CD40 Ligand Recombinant Protein

91-009 0.05 mg
EUR 364.25
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

CD40 Ligand Recombinant Protein

92-361 0.05 mg
EUR 490.25
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.

Mouse Cd40lg/ CD40 ligand ELISA Kit

E0252Mo 1 Kit
EUR 571

Recombinant Mouse soluble CD40 Ligand/TRAP

7-01474 5µg Ask for price

Recombinant Mouse soluble CD40 Ligand/TRAP

7-01475 25µg Ask for price

Recombinant Mouse soluble CD40 Ligand/TRAP

7-01476 1mg Ask for price

Anti-CD40/Cd40 Antibody

A00068-1 100ug/vial
EUR 294

Macaca mulatta CD40 ligand (CD40LG)

1-CSB-EP004937MOW
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Macaca mulatta CD40 ligand(CD40LG),partial expressed in E.coli

CD40LG/TNFSF5 (Cd40 Ligand) Antibody

20-abx111483
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

CD40 Ligand (CD40LG) Antibody (HRP)

20-abx306370
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

CD40 Ligand (CD40LG) Antibody (FITC)

20-abx306371
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

CD40 Ligand (CD40LG) Antibody (Biotin)

20-abx306372
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

soluble CD40 Ligand / TRAP Protein

20-abx260376
  • EUR 230.00
  • EUR 1859.00
  • EUR 328.00
  • 10 ug
  • 1 mg
  • 50 ug

soluble CD40 Ligand / TRAP Protein

20-abx260744
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

Soluble CD40 Ligand / TRAP Protein

20-abx261655
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug

Soluble CD40 Ligand Recombinant Protein

40-455-0005mg 0.005 mg
EUR 259.25
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Soluble CD40 Ligand Recombinant Protein

40-455-0025mg 0.025 mg
EUR 364.25
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)

CU78-10ug 10ug
EUR 141
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)

CU78-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)

CU78-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse CD40 ligand/CD40LG (N-6His)

CU78-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

anti-CD40

YF-PA10796 50 ul
EUR 363
Description: Mouse polyclonal to CD40

anti-CD40

YF-PA10797 50 ug
EUR 363
Description: Mouse polyclonal to CD40

anti-CD40

YF-PA23398 50 ul
EUR 334
Description: Mouse polyclonal to CD40

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Chicken CD40LG/ CD40 ligand ELISA Kit

E0014Ch 1 Kit
EUR 717

Pig CD40LG/ CD40 ligand ELISA Kit

E0034Pi 1 Kit
EUR 717

Bovine CD40LG/ CD40 ligand ELISA Kit

E0055Bo 1 Kit
EUR 717

Rat Cd40lg/ CD40 ligand ELISA Kit

E0179Ra 1 Kit
EUR 646

Human CD40 Ligand, CD40LG ELISA Kit

DEIA091 15 Plates
EUR 2408
Description: Human CD40 Ligand ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant CD40 Ligand in a sandwich ELISA format within the range of 50-3,000 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay CD40 Ligand in approximately 1,500 ELISA plate wells.

Human CD40LG/ CD40 ligand ELISA Kit

E0425Hu 1 Kit
EUR 537

Recombinant Human soluble CD40 Ligand/TRAP

7-01468 10µg Ask for price

Recombinant Human soluble CD40 Ligand/TRAP

7-01469 50µg Ask for price

Recombinant Human soluble CD40 Ligand/TRAP

7-01470 1mg Ask for price

ELISA kit for Human CD40 ligand

EK1310 96 tests
EUR 452
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Bovine CD40 ligand

EK1311 96 tests
EUR 670
Description: Enzyme-linked immunosorbent assay kit for quantification of Bovine CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids.

Recombinant Human CD40 Ligand/CD40L/TNFSF5

CI56-10ug 10ug
EUR 146
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5

CI56-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5

CI56-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5

CI56-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

QuickDetect? CD40 Ligand (Human) ELISA Kit

K4414-100
EUR 588

CD40 Ligand Recombinant Protein (Animal Free)

40-759 10 ug
EUR 269.75
Description: CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

Mouse Anti-Human CD40 mAb

CM005-100ug 100ug
EUR 245

Mouse Anti-Human CD40 mAb

CM005-25ug 25ug
EUR 136

Anti-CD40 Antibody

PA1019 100ug/vial
EUR 294

Anti-CD40 Antibody

PA1019-1 100ug/vial
EUR 294

Anti-CD40 Antibody

PB10051 100ug/vial
EUR 294

Anti-CD40 Antibody

PB10052 100ug/vial
EUR 334

Anti-CD40 antibody

STJ118037 100 µl
EUR 277
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Anti-CD40 antibody

STJ23000 100 µl
EUR 277
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Anti-CD40 antibody

STJ16100844 200 µg
EUR 814

Anti-CD40 antibody

STJ170001 100 µg
EUR 341
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin

Anti-CD40 antibody

STJ97928 100 µl
EUR 234
Description: Mouse monoclonal to CD40.

Anti-CD40 antibody

STJ92128 200 µl
EUR 197
Description: Rabbit polyclonal to CD40.

anti- CD40 antibody

FNab01477 100µg
EUR 505.25
Description: Antibody raised against CD40

anti-CD40 (9G10)

LF-MA30304 100 ul
EUR 486
Description: Mouse Monoclonal to CD40

Anti-CD40 antibody

PAab01477 100 ug
EUR 355

Anti-CD40 (1G1)

YF-MA12337 100 ug
EUR 363
Description: Mouse monoclonal to CD40

sCD40L Mouse, soluble CD40 Ligand/TRAPMouse Recombinant Protein, sf9

PROTP27548-1 Regular: 5ug
EUR 317
Description: sCD40 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 155 amino acids (112-260 a.a.) and having a molecular mass of 17.2kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).;sCD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant

P1174-10
EUR 164

Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant

P1174-50
EUR 555

Rhesus macaque CD40 Ligand / TNFSF5 Recombinant Protein

11-500 0.1 mg
EUR 542.75
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.

Mouse Anti Human Cd40 Monoclonal Antibody

CABT-46037MH 0.1 mg
EUR 710

Rat Anti Mouse Cd40 Monoclonal Antibody

CABT-46051RM 0.1 mg
EUR 455

Mouse Anti-Human CD40 mAbConjugated Antibody

CCM005 100ul
EUR 397

Mouse Monoclonal Anti-Human CD40, Unlabeled

CD40UL-100 100 ug
EUR 408

Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant

P1127-10
EUR 142

Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant

P1127-50
EUR 479

Anti-human CD40 antibody

STJ15100139 250 µg
EUR 273
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation.

Anti-human CD40 antibody

STJ15100140 250 µg
EUR 305
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections.

Anti-human CD40 antibody

STJ15100143 250 µg
EUR 273
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation.

Anti-Hu CD40 FITC

1F-416-T025 25 tests
EUR 122

Anti-Hu CD40 FITC

1F-416-T100 100 tests
EUR 204

Anti-Hu CD40 PE

1P-416-T025 25 tests
EUR 140

Anti-Hu CD40 PE

1P-416-T100 100 tests
EUR 240

Recombinant Human soluble CD40 Ligand/TRAP His Tag

7-01471 5µg Ask for price

Recombinant Human soluble CD40 Ligand/TRAP His Tag

7-01472 20µg Ask for price

Recombinant Human soluble CD40 Ligand/TRAP His Tag

7-01473 1mg Ask for price

Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli)

C011-10ug 10ug
EUR 100
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli)

C011-1mg 1mg
EUR 943
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.

mRNA expression evaluation of the resistant versus parental cell strains confirmed a major alteration in FAS expression between delicate and resistant cell strains (p = 0.03), whereas pathway evaluation revealed alterations in mRNA signaling pathways of Fas. On the idea of the pre-clinical knowledge obtained, it may be concluded that downregulation of Fas-receptor can mediate resistance to APO010. Osteoclast exercise was assessed utilizing a pit formation assay. The mechanisms of inhibition have been studied by biochemical analyses, together with RT-PCR, immunofluorescent staining, circulation cytometry, an apoptosis assay, immunoblotting, and ELISA.