Amongst 188 sufferers, 58 (30.9%) have been recognized with sepsis and 84 (44.7%) with septic shock, respectively. Plasma ranges of FasL elevated within the group order of management, sepsis, and septic shock teams (P for pattern < 0.001). For 142 sufferers with sepsis, organ dysfunction and septic shock have been extra prevalent within the group with plasma FasL ranges that have been increased than one of the best cut-off stage. A big distinction in mortality between excessive and low FasL sufferers was noticed as much as 90 days (Log-rank P = 0.013). FasL ranges didn’t considerably change over day Three and day 7. FasL ranges weren’t correlated with these of RIPK3.
Serum ranges of soluble Fas and Fas ligand in pregnant ladies who smoke
Cigarette smoking throughout being pregnant is related to lowered incidence of preeclampsia. Mechanisms of this affiliation are poorly understood. Cytokines, angiogenic and anti-angiogenic components are concerned within the pathogenesis of preeclampsia. Throughout regular being pregnant, Fas ligand (FasL) current on trophoblasts induces apoptosis of Fas bearing maternal immune cells. In preeclampsia, trophoblasts present elevated apoptosis with lowered expression of FasL. We decided serum ranges of cytokines, angiogenic (placental development issue), anti-angiogenic components (soluble endoglin, soluble fms-like tyrosine kinase-1), soluble Fas (sFas) and soluble FasL (sFasL) in smoking and non-smoking pregnant ladies.
Utilizing enzyme linked immunosorbent and multiplex assays, we prospectively analyzed serum ranges of angiogenic, anti-angiogenic components, cytokines, sFas and sFasL in normotensive smoking and non-smoking moms. Exclusion standards included maternal hypertension, autoimmune issues, rupture of membranes, proof of labor and drug use. We handled murine macrophages with DCR3 throughout receptor activator of nuclear issue kappa Β ligand- (RANKL-) plus IL-1α-induced osteoclastogenesis to observe osteoclast formation by tartrate-resistant acid phosphatase (TRAP) staining.
Of 100 ladies recruited to the examine, 51 have been within the non-smoking and 49 within the smoking group. Aside from decrease maternal age within the smoking group, there was no distinction in gestation, BMI, gravidity or ethnicity between the 2 teams. Ranges of angiogenic, anti-angiogenic components, cytokines and sFas have been related between the 2 teams however sFasL ranges have been considerably increased in smoking group (38 pg/ml vs. 16 pg/ml, p <0.001) and remained important after controlling for confounders.
Our examine demonstrates increased sFasL ranges in pregnant ladies who smoke. Greater sFasL could clarify the lowered incidence of preeclampsia in pregnant moms who smoke by inducing apoptosis of immune cells which can in any other case induce trophoblast apoptosis. MicroRNAs (miRNAs) are thought-about as essential modulators in myocardial ischemia and reperfusion (I/R) damage. The current examine aimed to analyze the expression and organic features of miR-214-5p through concentrating on Fas ligand (FASLG) in I/R damage.

Characterization of resistance to a recombinant hexameric Fas–ligand (APO010) in human most cancers cell strains
A number of myeloma stays a hard-to-treat most cancers as all sufferers finally progress due to drug resistance. Thus, there’s a want for novel and non-cross-resistant therapy choices, and we aimed to deal with this problem by introducing a brand new immuno-oncology drug (APO010) in a number of myeloma therapy. APO010 is a hexameric Fas-ligand that mimics cytotoxic T-lymphocyte signaling via the Fas-receptor to induce apoptosis. APO010 is at the moment in scientific trials with a number of myeloma sufferers.
Thus, an understanding of the mechanisms contributing to resistance to APO010 shall be important for future scientific research with APO010, and it may be doable to develop methods to bypass this resistance. We developed APO010-resistant variants of human a number of myeloma cell strains (LP1, MOLP-8, and KMS-12-BM) and a human Burkitt’s lymphoma cell line (Raji) by exposing the cells to steadily rising concentrations of APO010 over a interval of 6-12 months.
The resistant cell strains have been characterised on the idea of immunocytochemistry, Fas-receptor protein expression, mRNA expression evaluation, and pathway evaluation. APO010-resistant cell strains exhibited a 4- to 520-fold enhance in resistance to APO010 and nonetheless remained delicate to different chemotherapeutics. Downregulation of the Fas-receptor protein expression was noticed in all resistant cell strains.
CD40 ligand protein |
80R-4345 |
Fitzgerald |
10 ug |
EUR 327 |
Description: Purified Recombinant CD40 ligand protein (His tagged) |
Human CD40 ligand (CD40LG) |
1-CSB-RP060054h |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in E.coli |
Human CD40 ligand (CD40LG) |
1-CSB-YP004937HU1 |
Cusabio |
-
EUR 430.00
-
EUR 234.00
-
EUR 1508.00
-
EUR 642.00
-
EUR 1009.00
-
EUR 291.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human CD40 ligand(CD40LG),partial expressed in Yeast |
Rabbit CD40 ligand (CD40LG) |
1-CSB-YP004937RB |
Cusabio |
-
EUR 679.00
-
EUR 335.00
-
EUR 2172.00
-
EUR 1051.00
-
EUR 1442.00
-
EUR 435.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in Yeast |
Rabbit CD40 ligand (CD40LG) |
1-CSB-EP004937RB |
Cusabio |
-
EUR 611.00
-
EUR 309.00
-
EUR 1827.00
-
EUR 939.00
-
EUR 1218.00
-
EUR 397.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Rabbit CD40 ligand(CD40LG),partial expressed in E.coli |
CD40 Ligand/TRAP (Soluble) |
PR27033 |
Neuromics |
50 ug |
EUR 507 |
CD40 Ligand (CD40LG) Antibody |
20-abx306369 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
CD40 Ligand (CD40LG) Antibody |
abx146725-100ug |
Abbexa |
100 ug |
EUR 439 |
|
CD40 Ligand (CD40LG) Antibody |
abx146726-100ug |
Abbexa |
100 ug |
EUR 439 |
|
CD40 Ligand (CD40LG) Antibody |
abx146208-100ug |
Abbexa |
100 ug |
EUR 391 |
|
CD40 Ligand (CD40LG) Antibody |
20-abx000686 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
CD40 Ligand (CD40LG) Antibody |
20-abx211981 |
Abbexa |
|
|
|
CD40 Ligand Recombinant Protein |
96-984 |
ProSci |
0.1 mg |
EUR 542.75 |
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. |
CD40 Ligand Recombinant Protein |
96-985 |
ProSci |
0.1 mg |
EUR 542.75 |
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, alpha5beta1 integrin and alphaIIbbeta3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. |
CD40 Ligand Recombinant Protein |
91-009 |
ProSci |
0.05 mg |
EUR 364.25 |
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. |
CD40 Ligand Recombinant Protein |
92-361 |
ProSci |
0.05 mg |
EUR 490.25 |
Description: CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. |
Mouse Cd40lg/ CD40 ligand ELISA Kit |
E0252Mo |
Sunlong |
1 Kit |
EUR 571 |
Recombinant Mouse soluble CD40 Ligand/TRAP |
7-01474 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Mouse soluble CD40 Ligand/TRAP |
7-01475 |
CHI Scientific |
25µg |
Ask for price |
Recombinant Mouse soluble CD40 Ligand/TRAP |
7-01476 |
CHI Scientific |
1mg |
Ask for price |
Anti-CD40/Cd40 Antibody |
A00068-1 |
BosterBio |
100ug/vial |
EUR 294 |
Macaca mulatta CD40 ligand (CD40LG) |
1-CSB-EP004937MOW |
Cusabio |
-
EUR 611.00
-
EUR 309.00
-
EUR 1827.00
-
EUR 939.00
-
EUR 1218.00
-
EUR 397.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Macaca mulatta CD40 ligand(CD40LG),partial expressed in E.coli |
CD40LG/TNFSF5 (Cd40 Ligand) Antibody |
20-abx111483 |
Abbexa |
|
|
|
CD40 Ligand (CD40LG) Antibody (HRP) |
20-abx306370 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
CD40 Ligand (CD40LG) Antibody (FITC) |
20-abx306371 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
CD40 Ligand (CD40LG) Antibody (Biotin) |
20-abx306372 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
soluble CD40 Ligand / TRAP Protein |
20-abx260376 |
Abbexa |
-
EUR 230.00
-
EUR 1859.00
-
EUR 328.00
|
|
|
soluble CD40 Ligand / TRAP Protein |
20-abx260744 |
Abbexa |
-
EUR 3418.00
-
EUR 328.00
-
EUR 230.00
|
|
|
Soluble CD40 Ligand / TRAP Protein |
20-abx261655 |
Abbexa |
-
EUR 3418.00
-
EUR 328.00
-
EUR 230.00
|
|
|
Soluble CD40 Ligand Recombinant Protein |
40-455-0005mg |
ProSci |
0.005 mg |
EUR 259.25 |
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L. |
Soluble CD40 Ligand Recombinant Protein |
40-455-0025mg |
ProSci |
0.025 mg |
EUR 364.25 |
Description: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L. |
Recombinant Mouse CD40 ligand/CD40LG (N-6His) |
CU78-10ug |
Novoprotein |
10ug |
EUR 141 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse CD40 ligand/CD40LG (N-6His) |
CU78-1mg |
Novoprotein |
1mg |
EUR 1674 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse CD40 ligand/CD40LG (N-6His) |
CU78-500ug |
Novoprotein |
500ug |
EUR 1186 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse CD40 ligand/CD40LG (N-6His) |
CU78-50ug |
Novoprotein |
50ug |
EUR 303 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
anti-CD40 |
YF-PA10796 |
Abfrontier |
50 ul |
EUR 363 |
Description: Mouse polyclonal to CD40 |
anti-CD40 |
YF-PA10797 |
Abfrontier |
50 ug |
EUR 363 |
Description: Mouse polyclonal to CD40 |
anti-CD40 |
YF-PA23398 |
Abfrontier |
50 ul |
EUR 334 |
Description: Mouse polyclonal to CD40 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
Chicken CD40LG/ CD40 ligand ELISA Kit |
E0014Ch |
Sunlong |
1 Kit |
EUR 717 |
Pig CD40LG/ CD40 ligand ELISA Kit |
E0034Pi |
Sunlong |
1 Kit |
EUR 717 |
Bovine CD40LG/ CD40 ligand ELISA Kit |
E0055Bo |
Sunlong |
1 Kit |
EUR 717 |
Rat Cd40lg/ CD40 ligand ELISA Kit |
E0179Ra |
Sunlong |
1 Kit |
EUR 646 |
Human CD40 Ligand, CD40LG ELISA Kit |
DEIA091 |
Creative Diagnostics |
15 Plates |
EUR 2408 |
Description: Human CD40 Ligand ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant CD40 Ligand in a sandwich ELISA format within the range of 50-3,000 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay CD40 Ligand in approximately 1,500 ELISA plate wells. |
Human CD40LG/ CD40 ligand ELISA Kit |
E0425Hu |
Sunlong |
1 Kit |
EUR 537 |
Recombinant Human soluble CD40 Ligand/TRAP |
7-01468 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human soluble CD40 Ligand/TRAP |
7-01469 |
CHI Scientific |
50µg |
Ask for price |
Recombinant Human soluble CD40 Ligand/TRAP |
7-01470 |
CHI Scientific |
1mg |
Ask for price |
ELISA kit for Human CD40 ligand |
EK1310 |
SAB |
96 tests |
EUR 452 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids. |
ELISA kit for Bovine CD40 ligand |
EK1311 |
SAB |
96 tests |
EUR 670 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Bovine CD40 ligand in samples from serum, plasma, tissue homogenates and other biological fluids. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-10ug |
Novoprotein |
10ug |
EUR 146 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-1mg |
Novoprotein |
1mg |
EUR 2283 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-500ug |
Novoprotein |
500ug |
EUR 1613 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-50ug |
Novoprotein |
50ug |
EUR 303 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
QuickDetect? CD40 Ligand (Human) ELISA Kit |
K4414-100 |
Biovision |
|
EUR 588 |
CD40 Ligand Recombinant Protein (Animal Free) |
40-759 |
ProSci |
10 ug |
EUR 269.75 |
Description: CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L. |
Mouse Anti-Human CD40 mAb |
CM005-100ug |
SAB |
100ug |
EUR 245 |
Mouse Anti-Human CD40 mAb |
CM005-25ug |
SAB |
25ug |
EUR 136 |
Anti-CD40 Antibody |
PA1019 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD40 Antibody |
PA1019-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD40 Antibody |
PB10051 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD40 Antibody |
PB10052 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-CD40 antibody |
STJ118037 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Anti-CD40 antibody |
STJ23000 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Anti-CD40 antibody |
STJ170001 |
St John's Laboratory |
100 µg |
EUR 341 |
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin |
Anti-CD40 antibody |
STJ97928 |
St John's Laboratory |
100 µl |
EUR 234 |
Description: Mouse monoclonal to CD40. |
Anti-CD40 antibody |
STJ92128 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to CD40. |
anti- CD40 antibody |
FNab01477 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against CD40 |
anti-CD40 (9G10) |
LF-MA30304 |
Abfrontier |
100 ul |
EUR 486 |
Description: Mouse Monoclonal to CD40 |
Anti-CD40 (1G1) |
YF-MA12337 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to CD40 |
sCD40L Mouse, soluble CD40 Ligand/TRAPMouse Recombinant Protein, sf9 |
PROTP27548-1 |
BosterBio |
Regular: 5ug |
EUR 317 |
Description: sCD40 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 155 amino acids (112-260 a.a.) and having a molecular mass of 17.2kDa (Migrates at 18-28kDa on SDS-PAGE under reducing conditions).;sCD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. |
Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant |
P1174-10 |
Biovision |
|
EUR 164 |
Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant |
P1174-50 |
Biovision |
|
EUR 555 |
Rhesus macaque CD40 Ligand / TNFSF5 Recombinant Protein |
11-500 |
ProSci |
0.1 mg |
EUR 542.75 |
Description: CD40 ligand is also known as CD40L, CD154, TNFSF5 and T-cell antigen Gp39, is a single-pass type I I membrane protein which belongs to the TNF superfamily of molecules. CD40 ligand is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells). Although all monomeric, dimeric and trimeric forms of soluble CD40 ligand can bind to CD40, the trimeric form of soluble CD40 ligand has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members.CD40 ligand binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40 ligand plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40 ligand has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. |
Mouse Anti-Human CD40 mAbConjugated Antibody |
CCM005 |
SAB |
100ul |
EUR 397 |
Mouse Monoclonal Anti-Human CD40, Unlabeled |
CD40UL-100 |
Alpha Diagnostics |
100 ug |
EUR 408 |
Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant |
P1127-10 |
Biovision |
|
EUR 142 |
Human CellExp? CD40 Ligand / TNFSF5 Protein, Fc Tag, Mouse recombinant |
P1127-50 |
Biovision |
|
EUR 479 |
Anti-human CD40 antibody |
STJ15100139 |
St John's Laboratory |
250 µg |
EUR 273 |
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation. |
Anti-human CD40 antibody |
STJ15100140 |
St John's Laboratory |
250 µg |
EUR 305 |
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections. |
Anti-human CD40 antibody |
STJ15100143 |
St John's Laboratory |
250 µg |
EUR 273 |
Description: This monoclonal antibody is suitable for studies of CD40 expression on cells and tissue sections and for studies of B-cell activation, proliferation and differentiation. |
Anti-Hu CD40 FITC |
1F-416-T025 |
ExBio |
25 tests |
EUR 122 |
Anti-Hu CD40 FITC |
1F-416-T100 |
ExBio |
100 tests |
EUR 204 |
Anti-Hu CD40 PE |
1P-416-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD40 PE |
1P-416-T100 |
ExBio |
100 tests |
EUR 240 |
Recombinant Human soluble CD40 Ligand/TRAP His Tag |
7-01471 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human soluble CD40 Ligand/TRAP His Tag |
7-01472 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human soluble CD40 Ligand/TRAP His Tag |
7-01473 |
CHI Scientific |
1mg |
Ask for price |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-10ug |
Novoprotein |
10ug |
EUR 100 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-1mg |
Novoprotein |
1mg |
EUR 943 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
mRNA expression evaluation of the resistant versus parental cell strains confirmed a major alteration in FAS expression between delicate and resistant cell strains (p = 0.03), whereas pathway evaluation revealed alterations in mRNA signaling pathways of Fas. On the idea of the pre-clinical knowledge obtained, it may be concluded that downregulation of Fas-receptor can mediate resistance to APO010. Osteoclast exercise was assessed utilizing a pit formation assay. The mechanisms of inhibition have been studied by biochemical analyses, together with RT-PCR, immunofluorescent staining, circulation cytometry, an apoptosis assay, immunoblotting, and ELISA.