Dephosphorylation of Fas-ligand and caveolin-1 is a prerequisite step in Fas-ligand – caveolin-1 complex formation and cell death stimulation.

Fas-ligand/CD178 belongs to the TNF household proteins and is the well-characterized inducer of cell demise. We confirmed beforehand that the interplay of Fas-ligand and caveolin-1 is important for Fas-ligand translocation to rafts, and the following induction of Fas-ligand-dependent cell demise. Each molecules can endure phosphorylation, nevertheless the function of the phosphorylation state of Fas-ligand and

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