Month: March 2021

    • Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis.

    Regulatory T cells (Treg ) suppress T effector cell proliferation and preserve immune homeostasis. Autoimmune liver illnesses persist regardless of excessive frequencies of Treg within the liver, suggesting that the native hepatic microenvironment may have an effect on Treg stability, survival, and performance. We hypothesized that interactions between Treg and endothelial cells throughout recruitment after

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    • Dephosphorylation of Fas-ligand and caveolin-1 is a prerequisite step in Fas-ligand – caveolin-1 complex formation and cell death stimulation.

    Fas-ligand/CD178 belongs to the TNF household proteins and is the well-characterized inducer of cell demise. We confirmed beforehand that the interplay of Fas-ligand and caveolin-1 is important for Fas-ligand translocation to rafts, and the following induction of Fas-ligand-dependent cell demise. Each molecules can endure phosphorylation, nevertheless the function of the phosphorylation state of Fas-ligand and

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